A synthetic non-caloric sweetener
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Aspartame

Item No. 26089

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-phenylalanine, 2-methyl ester
CAS Number
22839-47-0
Synonyms
  • L-Aspartyl-L-Phenylalanine methyl ester
Molecular Formula
C14H18N2O5
Formula Weight
294.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 2.5 mg/mlPBS (pH 7.2): 0.1 mg/ml
SMILES
O=C(OC)[C@@H](NC([C@H](CC(O)=O)N)=O)CC1=CC=CC=C1
InChi Code
InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1
InChi Key
IAOZJIPTCAWIRG-QWRGUYRKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $53

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    10 g

    $79

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    50 g

    $256

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    100 g

    $409

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Aspartame is a synthetic non-caloric sweetener that is metabolized to phenylalanine, aspartic acid, and methanol in the gut.1,2 Aspartame (80 mg/kg per day for 90 days) increases plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, induces hepatocyte degeneration and leukocyte infiltration in the liver, and reduces hepatic levels of reduced glutathione (GSH), oxidized glutathione (GSSG), and γ-glutamylcysteine (γ-GC) in mice.2 Formulations containing aspartame have been used as sweetening agents and flavor enhancers in foods and beverages.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Choudhary, A.K., and Pretorius, E. Revisiting the safety of aspartame. Nutr. Rev. 75(9), 718-730 (2017).

    2. Finamor, I., Pérez, S., Bressan, C.A., et al. Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice. Redox Biol. 11, 701-707 (2017).