An ACE inhibitor and aspartame metabolite
Related Products
Parent Compound(s)
26089Aspartame
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

L-Aspartyl-L-phenylalanine

Item No. 34197

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-phenylalanine
CAS Number
13433-09-5
Synonyms
  • α-Aspartylphenylalanine
  • Asp-Phe
Molecular Formula
C13H16N2O5
Formula Weight
280.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
SMILES
OC(C[C@H](N)C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)=O
InChi Code
InChI=1S/C13H16N2O5/c14-9(7-11(16)17)12(18)15-10(13(19)20)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,14H2,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1
InChi Key
YZQCXOFQZKCETR-UWVGGRQHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $107

    Add

    250 mg

    $182

    Add

    500 mg

    $424

    Add

    1 g

    $794

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    L-Aspartyl-L-phenylalanine is a dipeptide inhibitor of angiotensin-converting enzyme (ACE) and a metabolite of the synthetic non-caloric sweetener aspartame (Item No. 26089).1,2 It is formed from aspartame by intestinal intracellular esterases.2 L-Aspartyl-L-phenylalanine inhibits ACE with a Ki value of 11 µM for the rabbit enzyme.1 Serum levels of L-aspartyl-L-phenylalanine are positively associated with pancreatic ductal adenocarcinoma.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grobelny, D., and Galardy, R.E. A metabolite of aspartame inhibits angiotensin converting enzyme. Biochem. Biophys. Res. Commun. 128(2), 960-964 (1985).

    2. Tobey, N.A., and Heizer, W.D. Intestinal hydrolysis of aspartylphenylalanine--the metabolic product of aspartame. Gastroenterology 91(4), 931-937 (1986).

    3. Stolzenberg-Solomon, R.Z., Derkach, A., Moore, S., et al. Associations between metabolites and pancreatic cancer risk in a large prospective epidemiological study. Gut 69(11), 2008-2015 (2020).