An internal standard for the quantification of 10(E),12(Z)-conjugated linoleic acid
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Unlabeled Version(s)
9014510(E),12(Z)-Conjugated Linoleic Acid
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10(E),12(Z)-Conjugated Linoleic Acid-d7

Item No. 26482

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10E,12Z-octadecadienoic-16,16,17,17,18,18,18-d7 acid
Synonyms
  • 10E,12Z-CLA-d7
  • t10,c12-CLA-d7
  • trans-10,cis-12-Conjugated Linoleic Acid-d7
  • FA 18:2-d7
  • 10(E),12(Z)-Octadecadienoic Acid-d7
Molecular Formula
C18H25D7O2
Formula Weight
287.5
Purity
≥99% deuterated forms (d1-d7)
Formulation
A 2.5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly Soluble: 1-10 mg/ml
SMILES
[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])CC/C=C\C=C\CCCCCCCCC(O)=O
InChi Code
InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-9H,2-5,10-17H2,1H3,(H,19,20)/b7-6-,9-8+/i1D3,2D2,3D2
InChi Key
GKJZMAHZJGSBKD-IXFBFAMZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

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    Product Description

    10(E),12(Z)-Conjugated linoleic acid-d7 is intended for use as an internal standard for the quantification of 10(E),12(Z)-conjugated linoleic acid (Item No. 90145) by GC- or LC-MS. 10(E),12(Z)-Conjugated linoleic acid is an isomer of linoleic acid (Item Nos. 90150 | 21909 | 90150.1) that has been found in bovine milk products.1 It binds to peroxisome proliferator-activated receptor α (PPARα; IC50 = 200 nM) and activates PPARα in a reporter assay using COS-1 cells expressing the mouse receptor.2 10(E),12(Z)-Conjugated linoleic acid also inhibits stearoyl-CoA desaturase activity in mouse liver microsomes and tartrate-resistant acid phosphatase (TRAP) activity in media from primary human CD14+ monocytes.3,4 It induces apoptosis in LoVo and HT-29 colon cancer cells when used at a concentration of 100 µM.5 10(E),12(Z)-Conjugated linoleic acid reduces epididymal, perirenal, and subcutaneous white adipose tissue weights in hamsters fed an atherogenic diet.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oliveira, R., Faria, M., Silva, R., et al. Fatty acid profile of milk and cheese from dairy cows supplemented a diet with palm kernel cake. Molecules 20(8), 15434-15448 (2015).

    2. Moya-Camarena, S.Y., Heuvel, J.P.V., Blanchard, S.G., et al. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα. J. Lipid Res. 40(8), 1426-1433 (1999).

    3. Park, Y., Storkson, J.M., Ntambi, J.M., et al. Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10,cis-12 conjugated linoleic acid and its derivatives. Biochim. Biophys. Acta 1486(2-3), 285-292 (2000).

    4. Platt, I., and El-Sohemy, A. Effects of 9cis,11trans and 10trans, 12cis CLA on osteoclast formation and activity from human CD14+ monocytes. Lipids Health Dis. 8, 15 (2009).

    5. Kim, K.-J., Lee, J., Park, Y., et al. ATF3 mediates anti-cancer activity of trans-10, cis-12-conjugated linoleic acid in human colon cancer cells. Biomol. Ther. (Seoul) 23(2), 134-140 (2015).

    6. Simón, E., Macarulla, M.T., Churruca, I., et al. trans-10,cis-12 conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters. J. Nutr. Biochem. 17(2), 126-131 (2006).