An active metabolite of nebivolol
Related Products
Parent Compound(s)
23660Nebivolol (hydrochloride)
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Nebivolol O-β-D-Glucuronide

Item No. 26657

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3S,4S,5R,6R)-6-(1-(6-fluorochroman-2-yl)-2-((2-(6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
Molecular Formula
C28H33F2NO10
Formula Weight
581.6
Purity
≥95% (mixture of diastereomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly, heatedMethanol: slightly
SMILES
FC1=CC=C2C(CCC(C(O[C@@]3([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O3)CNCC(O)C4([H])CCC(C=C(F)C=C5)=C5O4)([H])O2)=C1
InChi Code
InChI=1S/C28H33F2NO10/c29-15-3-7-18-13(9-15)1-5-20(38-18)17(32)11-31-12-22(21-6-2-14-10-16(30)4-8-19(14)39-21)40-28-25(35)23(33)24(34)26(41-28)27(36)37/h3-4,7-10,17,20-26,28,31-35H,1-2,5-6,11-12H2,(H,36,37)/t17?,20?,21?,22?,23-,24-,25+,26-,28+/m0/s1
InChi Key
UCVWRMDTTYGOAE-WYHWAAJFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $270

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    Product Description

    Nebivolol O-β-D-glucuronide is an active metabolite of the β1-adrenergic receptor antagonist nebivolol (Item No. 23660).1,2 This product is a mixture of D-nebivolol-11-O-β-D-glucuronide, L-nebivolol-11-O-β-D-glucuronide, D-nebivolol-11'-O-β-D-glucuronide, and L-nebivolol-11'-O-β-D-glucuronide.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vieira, C.P., Neves, D.V., Cesarino, E.J., et al. An indirect stereoselective analysis of nebivolol glucuronides in plasma by LC-MS/MS: Application to clinical pharmacokinetics. J. Pharm. Biomed. Anal. 144, 25-30 (2017).

    2. O'Donnell, J.P., Owens, W., Duncan, J., et al. Glucuronidated Nebivolol Metabolites. (2007).