An active metabolite of rosuvastatin
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N-desmethyl Rosuvastatin (sodium salt hydrate)

Item No. 26682

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid, disodium salt, monohydrate
Molecular Formula
C21H24FN3O6S • 2Na [H2O]
Formula Weight
529.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly, heatedMethanol: slightly solubleWater: slightly soluble
SMILES
O[C@@H](C[C@@H](O)CC([O-])=O)/C=C/C(C(C1=CC=C(F)C=C1)=NC([N-][S](C)(=O)=O)=N2)=C2C(C)C.[Na+].[Na+].O
InChi Code
InChI=1S/C21H26FN3O6S.2Na.H2O/c1-12(2)19-17(9-8-15(26)10-16(27)11-18(28)29)20(13-4-6-14(22)7-5-13)24-21(23-19)25-32(3,30)31;;;/h4-9,12,15-16,26-27H,10-11H2,1-3H3,(H2,23,24,25,28,29);;;1H2/q;2*+1;/p-2/b9-8+;;;/t15-,16-;;;/m1.../s1
InChi Key
YIAPWJZVDLSKPL-HTAYYFEJSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $169

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    1 mg

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    Product Description

    N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin (Item No.18813).1,2 N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Macwan, J.S., Ionita, I.A., and Akhlaghi, F. A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Anal. Bioanal. Chem. 402(3), 1217-1227 (2012).

    2. Bai, X., Wang, X.P., He, G.D., et al. Simultaneous determination of rosuvastatin, rosuvastatin-5 S-lactone, and N-desmethyl rosuvastatin in human plasma by UPLC-MS/MS and its application to clinical study. Drug Res. (Stuttg.) 68(6), 328-334 (2018).