An internal standard for the quantification of 5-fluorouracil
Related Products
Unlabeled Version(s)
144165-Fluorouracil
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

5-Fluorouracil-13C,15N2

Item No. 26683

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-2,4(1H,3H)-pyrimidinedione-2-13C-1,3-15N2
CAS Number
1189423-58-2
Synonyms
  • 5-FU-13C,15N2
Molecular Formula
C3[13C]H3F[15N2]O2
Formula Weight
133.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O=C1[15NH][13C]([15NH]C=C1F)=O
InChi Code
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)/i4+1,6+1,7+1
InChi Key
GHASVSINZRGABV-XZQGXACKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $369

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-fluorouracil (5-FU; (Item No. 14416) by GC- or LC-MS. 5-FU is a prodrug form of the thymidylate synthase inhibitor fluorodeoxyuridylate (FdUMP).1 It is also converted to the active metabolites FUTP and FdUTP, which induce RNA and DNA damage, respectively. In vivo, 5-FU (15 mg/kg) when administered in combination with docetaxel (Item No. 11637) reduces tumor growth in B88 and CAL 27 oral squamous cell carcinoma (OSCC) mouse xenograft models.2 Formulations containing 5-FU have been used in the treatment of colorectal, breast, gastric, and pancreatic cancers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Longley, D.B., Harkin, D.P., and Johnston, P.G. 5-fluorouracil: Mechanisms of action and clinical strategies. Nat. Rev. Cancer 3(5), 330-338 (2003).

    2. Tamatani, T., Ferdous, T., Takamaru, N., et al. Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells. Int. J. Oncol. 41(3), 1148-1156 (2012).