An internal standard for the quantification of (–)-hyoscyamine
Related Products
Enantiomer(s)
12008Atropine
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(−)-Hyoscyamine-d3

Item No. 26760

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,3R,5S)-8-(methyl-d3)-8-azabicyclo[3.2.1]octan-3-yl (S)-3-hydroxy-2-phenylpropanoate
Synonyms
  • L-Hyoscyamine-d3
  • (S)-Hyoscyamine-d3
Molecular Formula
C17H20D3NO3
Formula Weight
292.4
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 50 mg/mlEthanol: solubleMethanol: soluble
SMILES
O=C([C@H](CO)C1=CC=CC=C1)O[C@H]2C[C@H]3CC[C@H](N3C([2H])([2H])[2H])C2
InChi Code
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16-/m1/s1/i1D3
InChi Key
RKUNBYITZUJHSG-KHCPMMLOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $908

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    Product Description

    (–)-Hyoscyamine-d3 is intended for use as an internal standard for the quantification of (–)-hyoscyamine by GC- or LC-MS. (–)-Hyoscyamine is a tropane alkaloid, a muscarinic receptor antagonist, and an isomer of atropine (Item No. 12008).1,2 (–)-Hyoscyamine inhibits the arterial depressor response induced by the muscarinic agonist methacholine in dogs.1 It is more effective than atropine at inhibiting EEG arousal in dogs following sciatic nerve stimulation when administered at doses of 0.5 and 1 mg/kg. (–)-Hyoscyamine induces convulsions in and is toxic to mice (LD50 = 95 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Domino, E.F., and Hudson, R.D. Observations on the pharmacological actions of the isomers of atropine. J. Pharmacol. Exp. Ther. 127(4), 305-312 (1959).

    2. Authority, E.F.S. Scientific Opinion on Tropane alkaloids in food and feed EFSA Panel on contaminants in the food chain (CONTAM). EFSA J. 11(10), 3386 (2013).