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ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICESNitenpyram-d3 is intended for use as an internal standard for the quantification of nitenpyram (Item No. 21271) by GC- or LC-MS. Nitenpyram is a neonicotinoid insecticide.1 It is an antagonist of housefly neuronal-type nicotinic acetylcholine receptors (nAChRs; IC50 = 2 nM for housefly head homogenates).2 Nitenpyram induces mortality in brown planthopper (N. lugens) larvae when used at a concentration of 0.5 ppm.3 Orally administered nitenpyram (11.4, 11.4, and 57 mg/animal, respectively) eliminates live adult fleas on cats, small dogs, and large dogs after six hours of treatment.4 It also reduces the number of aphids, ladybugs, ladybug larvae, lacewings, and syrphid larvae on adult cotton plants when applied to cotton seeds at a concentration of 4 g/kg of seeds.5 Formulations containing nitenpyram have been used in the control of fleas and ticks on companion animals.
WARNING This product is not for human or veterinary use.
1. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J. Vet. Pharmacol. Ther. 33(4), 315-322 (2010).
2. Ligands of the nicotinic acetylcholine receptor as insecticides. Pest. Manag. Sci. 55(5), 608-610 (1999).
3. Synthesis and insecticidal activity of acyclic nitroethene compounds containing a heteroarylmethylamino group. J. Pesticide Sci. 18, 41-48 (1993).
4. Efficacy of nitenpyram as a systemic flea adulticide in dogs and cats. Vet. Rec. 147(25), 709-713 (2000).
5. Nitenpyram, dinotefuran, and thiamethoxam used as seed treatments act as efficient controls against Aphis gossypii via high residues in cotton leaves. J. Agric. Food Chem. 64(49), 9276-9285 (2016).