A fluorogenic substrate for α-glucosidase
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4-Methylumbelliferyl-α-D-Glucopyranoside

Item No. 26810

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(α-D-glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one
CAS Number
17833-43-1
Synonyms
  • 4-Methylumbelliferyl-α-D-Glucose
  • 4-Methylumbelliferyl-α-D-Glucoside
  • 4-MU-α-D-Glucopyranoside
Molecular Formula
C16H18O8
Formula Weight
338.3
Purity
≥95%
Emission
445 to 455 nM, increasing as pH decreases
Excitation
320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 50 mg/ml
λmax
217, 318 nm
SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC2=CC=C(C(C)=CC(O3)=O)C3=C2)O1
InChi Code
InChI=1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/m1/s1
InChi Key
YUDPTGPSBJVHCN-JZYAIQKZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    Product Description

    4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase.1,2 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.3 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Olivova, P., van der Veen, K., Cullen, E., et al. Effect of sample collection on alpha-galactosidase A enzyme activity measurements in dried blood spots on filter paper. Clin. Chim. Acta. 403(1-2), 159-162 (2009).

    2. Wens, S.C., Kroos, M.A., de Vries, J.M., et al. Remarkably low fibroblast acid α-glucosidase activity in three adults with Pompe disease. Mol. Genet. Metab. 107(3), 485-489 (2012).

    3. Zhi, H., Wang, J., Wang, S., et al. Fluorescent properties of hymecromone and fluorimetric analysis of hymecromone in compound dantong capsule. J. Spectrosc. 147128 (2013).