An antagonist of L3MBTL1, L3MBTL3, and L3MBTL4
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UNC926

Item No. 27302

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3-bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-methanone
CAS Number
1184136-10-4
Molecular Formula
C16H21BrN2O
Formula Weight
337.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
SMILES
BrC1=CC=CC(C(N2CCC(N3CCCC3)CC2)=O)=C1
InChi Code
InChI=1S/C16H21BrN2O/c17-14-5-3-4-13(12-14)16(20)19-10-6-15(7-11-19)18-8-1-2-9-18/h3-5,12,15H,1-2,6-11H2
InChi Key
OWGLFIKZKQOYHZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $134

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    25 mg

    $315

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    50 mg

    $553

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    Product Description

    UNC926 is an antagonist of the MBT domain-containing methyl-lysine reader proteins L3MBTL1, L3MBTL3, and L3MBTL4.1 It inhibits methyl-lysine histone peptide substrate binding of L3MBTL1, L3MBTL3, and L3MBTL4 (IC50s =3.9, 3.2, and 15.6 μM, respectively) selectively over MBT domain-containing MBTD1 and SFMBT1 and chromo domain-containing CBX7 (IC50s = >30 μM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Herold, J.M., James, L.I., Korboukh, V.K., et al. Structure–activity relationships of methyl-lysine reader antagonists. Med. Chem. Commun. 3(1), 45-51 (2012).