An inhibitor of STK16
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STK16-IN-1

Item No. 27370

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one
CAS Number
1223001-53-3
Molecular Formula
C17H12FN3O
Formula Weight
293.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
FC1=CC=C(N2C(C(C=CC2=O)=CN3)=C4C3=NC=C4)C=C1C
InChi Code
InChI=1S/C17H12FN3O/c1-10-8-12(3-4-14(10)18)21-15(22)5-2-11-9-20-17-13(16(11)21)6-7-19-17/h2-9H,1H3,(H,19,20)
InChi Key
WQNRDXHKVSKUPI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $193

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    25 mg

    $424

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    50 mg

    $740

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    Product Description

    STK16-IN-1 is an inhibitor of the serine/threonine kinase STK16 (IC50 = 295 nM).1 It is selective for STK16 over mTOR, PI3Kδ, and PI3Kγ in an enzyme assay (IC50s = 5,560, 856, and 867 nM, respectively) and over 440 additional kinases in a KinomeScan profiling assay. It decreases the growth of MCF-7 cells (GI50 = ~10 µM) and increases the number of binucleated cells. STK16-IN-1 (2.5-5 µM) potentiates the antiproliferative effects of colchicine (Item No. 9000760), paclitaxel (Item No. 10461), doxorubicin (Item No. 15007), and cisplatin (Item No. 13119) in MCF-7 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, F., Wang, J., Yang, X., et al. Discovery of a highly selective STK16 kinase inhibitor. ACS Chem. Biol. 11(6), 1537-1543 (2016).