Nicotiflorin

Nicotiflorin is a flavonoid that has been found in I. glandulifera and has antioxidant and neuroprotective activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals with EC₅₀ values of 0.52 and 0.48 mg/ml, respectively, in cell-free assays.¹ Nicotiflorin (1 µM) prevents hydrogen peroxide-induced decreases in tyrosine hydroxylase activity in PC12 cells and cell death in primary rat mesencephalic neurons.² It decreases infarct volume by 24.5, 45.8, and 63.2% when administered at doses of 2.5, 5, and 10 mg/kg, respectively, in a rat model of cerebral ischemia-reperfusion injury induced by transient middle central artery occlusion (MCAO).³

WARNING This product is not for human or veterinary use.

1. Szewczyk, K., Sezai Cicek, S., Zidorn, C., et al. Phenolic constituents of the aerial parts of Impatiens glandulifera Royle (Balsaminaceae) and their antioxidant activities. Nat. Prod. Res. 33(19), 2851-2855 (2019).

2. Qu, W., Fan, L., Kim, Y.C., et al. Kaempferol derivatives prevent oxidative stress-induced cell death in a DJ-1-dependent manner. J. Pharmacol. Sci. 110(2), 191-200 (2009).

3. Li, R., Guo, M., Zhang, G., et al. Nicotiflorin reduces cerebral ischemic damage and upregulates endothelial nitric oxide synthase in primarily cultured rat cerebral blood vessel endothelial cells. J. Ethnopharmacol. 107(1), 143-150 (2006).