A muscarinic M1 receptor antagonist
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Trihexyphenidyl (hydrochloride)

Item No. 27643

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-cyclohexyl-α-phenyl-1-piperidinepropanol, monohydrochloride
CAS Number
52-49-3
Synonyms
  • Benzhexol hydrochloride
Molecular Formula
C20H31NO • HCl
Formula Weight
337.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 3 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
SMILES
OC(CCN1CCCCC1)(C2=CC=CC=C2)C3CCCCC3.Cl
InChi Code
InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
InChi Key
QDWJJTJNXAKQKD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $36

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    1 g

    $63

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    5 g

    $135

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    Product Description

    Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors.1 It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine (Item No. 23829) in guinea pig ileum (IC50 = 22 nM).2 It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH).3 Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giachetti, A., Giraldo, E., Ladinsky, H., et al. Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine. Br. J. Pharmacol. 89(1), 83-90 (1986).

    2. Fjalland, B., Christensen, A.V., and Hyttel, J. Peripheral and central muscarinic receptor affinity of psychotropic drugs. Naunyn. Schmiedebergs. Arch. Pharmacol. 301(1), 5-9 (1977).

    3. Rose, S.J., Yu, X.Y., Heinzer, A.K., et al. A new knock-in mouse model of ʟ-DOPA-responsive dystonia. Brain 138(Pt 10), 2987-3002 (2015).