(+)-Pinoresinol

(+)-Pinoresinol is a lignan that has been found in Forsythia and virgin olive oils and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.^1,2,3,4 It is an inhibitor of α-glucosidase and maltase (IC₅₀s = 492 and 34.3 µM in Baker’s yeast and rat small intestine, respectively).³ (+)-Pinoresinol scavenges ABTS (Item No. 27317), but not 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), radicals in cell-free assays (IC₅₀s = 13.43 and >200 µg/ml, respectively).² It is cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells with IC₅₀ values of 29.35, 62.35, 75.32, >80, and >80 µM, respectively. (+)-Pinoresinol prevents cell death induced by glutamate in HT22 cells (EC₅₀ = 6.96 µM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC₅₀ = 7.89 µM).⁴

WARNING This product is not for human or veterinary use.

1. López-Biedma, A., Sánchez-Quesada, C., Delgado-Rodríguez, M., et al. The biological activities of natural lignans from olives and virgin olive oils: A review. J. Funct. Foods 26, 36-47 (2016).

2. Li, D.-Q., Wang, D., Zhou, L., et al. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense. J. Asian Nat. Prod. Res. 19(5), 519-527 (2017).

3. Wikul, A., Damsud, T., Kataoka, K., et al. (+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting α-glucosidase. Bioorg. Med. Chem. Lett. 22(16), 5215-5217 (2012).

4. In, S.-J., Seo, K.-H., Song, N.-Y., et al. Lignans and neolignans from the stems of Vibrunum erosum and their neuroprotective and anti-inflammatory activity. Arch. Pharm. Res. 38(1), 26-34 (2015).