An Analytical Reference Material
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
Related Products
Certified Reference Material(s)
34184Brorphine (hydrochloride) (CRM)
Labeled Version(s)
31566Brorphine-d7 38145Brorphine-d7 (exempt preparation)
Metabolite(s)
37339nor-Orphine
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Brorphine (hydrochloride)

Item No. 27816

Restricted Product (Schedule I)
Product Insert (PDF)Technical Brief (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[1-[1-(4-bromophenyl)ethyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one, monohydrochloride
CAS Number
2707204-49-5
Molecular Formula
C20H22BrN3O • HCl
Formula Weight
436.8
Purity
≥98%
Formulation
A neat solid
SMILES
CC(C1=CC=C(Br)C=C1)N2CCC(N3C(NC4=C3C=CC=C4)=O)CC2.Cl
InChi Code
InChI=1S/C20H22BrN3O.ClH/c1-14(15-6-8-16(21)9-7-15)23-12-10-17(11-13-23)24-19-5-3-2-4-18(19)22-20(24)25;/h2-9,14,17H,10-13H2,1H3,(H,22,25);1H
InChi Key
ASWDEGDBUGKAOG-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Product Description

    Brorphine (hydrochloride) (Item No. 27816) is an analytical reference material categorized as an opioid.1,2 Brorphine induces respiratory depression in mice.2 Brorphine is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kennedy, N.M., Schmid, C.L., Ross, N.C., et al. Optimization of a series of mu opioid receptor (MOR) agonists with high G protein signaling bias. J. Med. Chem. 61(19), 8895-8907 (2018).

    2. Vandeputte, M.M., Bilel, S., Tirri, M., et al. Elucidating the harm potential of brorphine analogues as new synthetic opioids: Synthesis, in vitro, and in vivo characterization. Neuropharmacology 260, 110113 (2024).

    Product Citations

    Lenzi, M., Gasperini, S., Bilel, S., et al. New synthetic opioids: What do we know about the mutagenicity of brorphine and its analogues? Int. J. Mol. Sci. 26(11), 5084 (2025).

    Vandeputte, M.M., Cannaert, A., and Stove, C.P. In vitro functional characterization of a panel of non‑fentanyl opioid new psychoactive substances. Arch. Toxicol. 94(11), 3819-3830 (2020).

    Krotulski, A.J., Papsun, D.M., Noble, C., et al. Brorphine-investigation and quantitation of a new potent synthetic opioid in forensic toxicology casework using liquid chromatography-mass spectrometry. J. Forensic Sci. 66(2), 664-676 (2021).