A basic aluminum sucrose sulfate complex with gastroprotective activity
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Sucralfate (technical grade)

Item No. 27882

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
hexadeca-μ-hydroxytetracosahydroxy[μ8-[[1,3,4,6-tetra-O-sulfo-β-D-fructofuranosyl α-D-glucopyranoside tetrakis(sulfato-κO')](8-)]]hexadeca-aluminum
CAS Number
54182-58-0
Molecular Formula
C12H54Al16O75S8
Formula Weight
2086.7
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
aqueous acid: slightly soluble
SMILES
O=S(OC[C@@H]1[C@@H](OS(=O)([O-][Al+3]2([OH-][Al+3]([OH-])([OH-])[OH-]2)[OH-])=O)[C@H](OS(=O)([O-][Al+3]3([OH-][Al+3]([OH-])([OH-])[OH-]3)[OH-])=O)[C@](COS(=O)([O-][Al+3]4([OH-][Al+3]([OH-])([OH-])[OH-]4)[OH-])=O)(O[C@@]5([H])O[C@H](COS(=O)([O-][Al+3]6([OH-][Al+3]([OH-])([OH-])[OH-]6)[OH-])=O)[C@@H](OS(=O)([O-][Al+3]7([OH-][Al+3]([OH-])([OH-])[OH-]7)[OH-])=O)[C@H](OS(=O)([O-][Al+3]8([OH-][Al+3]([OH-])([OH-])[OH-]8)[OH-])=O)[C@H]5OS(=O)([O-][Al+3]9([OH-][Al+3]([OH-])([OH-])[OH-]9)[OH-])=O)O1)([O-][Al+3]%10([OH-][Al+3]([OH-])([OH-])[OH-]%10)[OH-])=O
InChi Code
InChI=1S/C12H22O35S8.16Al.40H2O/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;;;;;;;;;;;;;;;;40*1H2/q;16*+3;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/p-48/t4-,5-,6-,7-,8+,9-,10+,11-,12+;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/m1......................................................../s1
InChi Key
DTULOKYBGCTCFP-QRLOXDDHSA-A
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $36

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    1 g

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    Product Description

    Sucralfate is a basic aluminum sucrose sulfate complex that has gastroprotective activity.1 It inhibits rat pepsin in a concentration-dependent manner and pepsin activity in isolated human gastric juice. It also inhibits ulcer formation induced by pyloric ligation, indomethacin (Item No. 70270), or cysteamine (Item No. 22193) in rats. Sucralfate (5,600 mg/animal) is protective against neutral ethanol and acidified taurocholic acid-induced damage in a rat model of hydrochloric acid-induced gastric mucosal damage, increasing the pH and reducing the disappearance of hydrogen ions.2 Formulations containing sucralfate have been used as antacids in the treatment of duodenal ulcer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Borella, L.E., Seethaler, K., and Lippmann, W. Sucralfate: Antipeptic, antiulcer activities and antagonism of gastric emptying. Arzneimittelforschung 29(5), 793-798 (1979).

    2. Harrington, S.J., Schlegel, J.F., and Code, C.F. The protective effect of sucralfate on the gastric mucosa of rats. J. Clin. Gastroenterol. 3(Suppl 2), 129-134 (1981).