Fraxetin

Fraxetin is a coumarin that has been found in F. bungeana and has diverse biological activities.^1,2,3 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals, ABTS (Item No. 27317) radicals, and hydrogen peroxide in cell-free assays (IC₅₀s = 44.1, 37.4, and 40.5 μM, respectively).¹ Fraxetin selectively reduces cell viability in a panel of six non-small cell lung cancer (NSCLC) cell lines (IC₅₀s = 20.12-61.36 μM) over noncancerous cell lines (IC₅₀s = >100 μM).² Fraxetin (25 and 50 mg/kg) reduces levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBIL) in serum, decreases hepatic expression of TNF-α, IL-6, IL-1β, and COX-2, and attenuates hepatic fibrosis in a rat model of carbon tetrachloride-induced liver fibrosis.³

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1. Wu, C.-R., Huang, M.-Y., Lin, Y.-T., et al. Antioxidant properties of Cortex Fraxini and its simple coumarins. Food Chem. 104(4), 1464-1471 (2007).

2. Zhang, Y., Wang, L., Deng, Y., et al. Fraxetin suppresses proliferation of non-small-cell lung cancer cells via preventing activation of signal transducer and activator of transcription 3. Tohoku J. Exp. Med. 248(1), 3-12 (2019).

3. Wu, B., Wang, R., Li, S., et al. Antifibrotic effects of fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways. Pharmacol. Rep. 71(3), 409-416 (2019).