An active metabolite of silodosin
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Parent Compound(s)
14866Silodosin
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Silodosin Glucuronide (sodium salt)

Item No. 28045

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[7-(aminocarbonyl)-2,3-dihydro-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indol-1-yl]propyl, β-D-glucopyranosiduronic acid, monosodium salt
CAS Number
879292-24-7
Synonyms
  • Silodosin β-D-glucuronide
Molecular Formula
C31H39F3N3O10 • Na
Formula Weight
693.6
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly soluble
SMILES
C[C@H](CC1=CC(C(N)=O)=C(N(CCCO[C@@H]2O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]2O)CC3)C3=C1)NCCOC4=C(OCC(F)(F)F)C=CC=C4.[Na+]
InChi Code
InChI=1S/C31H40F3N3O10.Na/c1-17(36-8-12-44-21-5-2-3-6-22(21)46-16-31(32,33)34)13-18-14-19-7-10-37(23(19)20(15-18)28(35)41)9-4-11-45-30-26(40)24(38)25(39)27(47-30)29(42)43;/h2-3,5-6,14-15,17,24-27,30,36,38-40H,4,7-13,16H2,1H3,(H2,35,41)(H,42,43);/q;+1/p-1/t17-,24+,25+,26-,27+,30-;/m1./s1
InChi Key
SSXDGVSHJRFUEJ-XNUWQVEGSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $369

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    Product Description

    Silodosin glucuronide is an active metabolite of the α1A-adrenergic receptor antagonist silodosin (Item No. 14866).1,2 It is formed from silodosin by the UDP-glucuronosyltransferase (UGT) isoform UGT2B7.1 Silodosin glucuronide is toxic to rats with an LD50 value of 0.347 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Keating, G.M. Silodosin: A review of its use in the treatment of the signs and symptoms of benign prostatic hyperplasia. Drugs 75(2), 207-217 (2015).

    2. Vishnuvardhan, C., Baikadi, S., Borkar, R.M., et al. In vivo metabolic investigation of silodosin using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites. J. Mass. Spectrom. 51(10), 867-882 (2016).