A major metabolite of voriconazole
Related Products
Labeled Version(s)
40332Voriconazole-d3 N-oxide
Parent Compound(s)
15633Voriconazole
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Voriconazole N-oxide

Item No. 28047

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,βS)-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol, 1-oxide
CAS Number
618109-05-0
Synonyms
  • UK 121265
Molecular Formula
C16H14F3N5O2
Formula Weight
365.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
FC1=C[N+]([O-])=CN=C1[C@@H]([C@](O)(CN2N=CN=C2)C3=C(C=C(C=C3)F)F)C
InChi Code
InChI=1S/C16H14F3N5O2/c1-10(15-14(19)5-24(26)9-21-15)16(25,6-23-8-20-7-22-23)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
InChi Key
KPLFPLUCFPRUHU-MGPLVRAMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $180

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    5 mg

    $536

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    Product Description

    Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole (Item No. 15633).1 It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyland, R., Jones, B.C., and Smith, D.A. Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole. Drug Metab. Dispos. 31(5), 540-547 (2003).