An internal standard for the quantification of voriconazole N-oxide
Related Products
Unlabeled Version(s)
28047Voriconazole N-oxide
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Voriconazole-d3 N-oxide

Item No. 40332

Technical Information
Formal Name
(αR,βS)-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol-d3, 1-oxide
CAS Number
1217851-84-7
Molecular Formula
C16H11D3F3N5O2
Formula Weight
Purity
≥99% deuterated forms (d1-d3)
A 1 mg/ml solution in ethanol
Ethanol: Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
FC1=C[N+]([O-])=CN=C1[C@@H]([C@](O)(CN2N=CN=C2)C3=C(C=C(C=C3)F)F)C([2H])([2H])[2H]
InChi Code
InChI=1S/C16H14F3N5O2/c1-10(15-14(19)5-24(26)9-21-15)16(25,6-23-8-20-7-22-23)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1/i1D3
InChi Key
KPLFPLUCFPRUHU-QLWAGJNOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Voriconazole-d3 N-oxide is intended for use as an internal standard for the quantification of voriconazole N-oxide (Item No. 28047) by GC- or LC-MS. Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole (Item No. 15633).1 It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyland, R., Jones, B.C., and Smith, D.A. Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole. Drug Metab. Dispos. 31(5), 540-547 (2003).