A PEGylated form of DSPE
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DSPE-mPEG(2000) (sodium salt)

Item No. 28181

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-poly(oxy-1,2-ethanediyl), monosodium salt
CAS Number
247925-28-6
Synonyms
  • 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-methoxy-Polyethylene Glycol-2000
  • 1,2-Dioctadecanoyl-sn-glycero-3-Phosphoethanolamine-N-mPEG(2000)
  • PtdEtn-(1,2-Distearoyl)-N-mPEG(2000)
  • 1,2-Distearoyl Phosphatidylethanolamine-N-mPEG(2000)
  • PE(18:0/18:0)-mPEG(2000)
  • 1,2-DSPE-mPEG(2000)
Molecular Formula
(C2H4O)n C43H83NO10P • Na
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/mlDMF: 2.5 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O=[P](OCCNC(OCCOC)=O)([O-])OCC(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O.[Na+]
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    100 mg

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    250 mg

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    500 mg

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    Cayman Chemical
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    Product Description

    DSPE-mPEG(2000) is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095). Formulations containing DSPE-mPEG(2000) have been used in the synthesis of liposomes for the delivery of anticancer and antimalarial agents.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hasan, G.M., Garg, N., Dogra, E., et al. Inhibition of the growth of Plasmodium falciparum in culture by stearylamine-phosphatidylcholine liposomes. J. Parasitol. Res. 120462 (2011).

    2. Rathore, S.S., and Ghosh, P.C. Effect of surface charge and density of distearylphosphatidylethanolamine-mPEG-2000 (DSPE-mPEG-2000) on the cytotoxicity of liposome-entrapped ricin: Effect of lysosomotropic agents. Int. J. Pharm. 350(1-2), 79-94 (2008).

    3. Haghiralsadat, F., Amoabediny, G., Helder, M.N., et al. A comprehensive mathematical model of drug release kinetics from nano-liposomes, derived from optimization studies of cationic PEGylated liposomal doxorubicin formulations for drug-gene delivery. Artif. Cells Nanomed. Biotechnol. 46(1), 169-177 (2018).