An inhibitor of NOD1 and NOD2
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NOD-IN-1

Item No. 28370

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-methylphenyl)sulfonyl]-1H-indole-2-carboxylic acid, ethyl ester
CAS Number
132819-92-2
Molecular Formula
C18H17NO4S
Formula Weight
343.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
216, 271 nm
SMILES
O=C(OCC)C1=CC2=CC=CC=C2N1S(C3=CC=C(C)C=C3)(=O)=O
InChi Code
InChI=1S/C18H17NO4S/c1-3-23-18(20)17-12-14-6-4-5-7-16(14)19(17)24(21,22)15-10-8-13(2)9-11-15/h4-12H,3H2,1-2H3
InChi Key
OJMOGUKIYRAILM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    NOD-IN-1 is an inhibitor of nucleotide-binding oligomerization domain (NOD) receptors and a derivative of nodinitib-1 (Item No. 11040).1 NOD-IN-1 inhibits C12-iE-DAP-induced NF-ĸB activation in HEK-Blue cells expressing human recombinant NOD1 or NOD2 (IC50s = 5.74 and 6.45 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Keček Plešec, K., Urbančič, D., Gobec, M., et al. Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2. Bioorg. Med. Chem. 24(21), 5221-5234 (2016).