An oxazolidinone antibiotic
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PNU 100480

Item No. 28395

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(5S)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
CAS Number
168828-58-8
Synonyms
  • Sutezolid
  • U 100480
Molecular Formula
C16H20FN3O3S
Formula Weight
353.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3mg/mLDMSO: 10mg/mLDMSO:PBS (pH 7.2) (1:6): 0.14mg/mL
λmax
205, 259 nm
SMILES
CC(NC[C@@H](CN1C2=CC=C(N3CCSCC3)C(F)=C2)OC1=O)=O
InChi Code
InChI=1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
InChi Key
FNDDDNOJWPQCBZ-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis.1 It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid (Item No. 20378), rifampin (rifampicin; Item No. 14423), ethambutol (Item No. 23713), and streptomycin (Item No. 21211; MICs = ≤0.0625-0.5 mg/L).1,2 It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml).3 PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alffenaar, J.W., van der Laan, T., Simons, S., et al. Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480. Antimicrob. Agents Chemother. 55(3), 1287-1289 (2011).

    2. Zhang, M., Sala, C., Dhar, N., et al. In vitro and in vivo activities of three oxazolidinones against nonreplicating Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 58(6), 3217-3223 (2014).

    3. Loreto, E.S., Tondolo, J.S.M., Oliveira, D.C., et al. In vitro activities of miltefosine and antibacterial agents from the macrolide, oxazolidinone, and pleuromutilin classes against Pythium insidiosum and Pythium aphanidermatum. Antimicrob. Agents Chemother. 62(3), e01678-01617 (2018).