An aminoglycoside antibiotic
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Streptomycin (sulfate)

Item No. 21211

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-D-streptamine
CAS Number
3810-74-0
Molecular Formula
C21H39N7O12 • 1.5H2SO4
Formula Weight
728.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 13 mg/mlDMSO: 2 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
231 nm
SMILES
NC(N[C@@H]1[C@@H](O)[C@H](NC(N)=N)[C@](O[C@H]2[C@H](O[C@]3([H])O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3NC)[C@](C=O)(O)[C@H](C)O2)([H])[C@H](O)[C@H]1O)=N.OS(=O)(O)=O.OS(=O)(O)=O
InChi Code
InChI=1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7+,8-
InChi Key
QTENRWWVYAAPBI-YCRXJPFRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 g

    $29

    Add

    50 g

    $50

    Add

    100 g

    $82

    Add

    250 g

    $190

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Streptomycin is an aminoglycoside antibiotic that inhibits growth of both Gram-negative (MICs = 1 and 16 μg/mL for K. pneumoniae and S. marcescens, respectively) and Gram-positive bacteria (MIC = 0.25 μg/mL for S. pneumoniae).1 It inhibits growth of M. tuberculosis H37Rv (MIC = 5 μg/mL) and of susceptible strains from clinical isolates (MICs = ≤0.125-1 μg/mL).2,3 Streptomycin (150 mg/kg), in combination with isoniazid (Item No. 20378), rifapentine (Item No. 20307), and moxifloxacin (Item No. 14830), administered once per week over 6 months to M. tuberculosis-inoculated mice results in clearance of the pathogen from the lungs of the majority of treated mice.4 However, after 3 months without treatment, 58% of treated mice produce a positive lung culture. Streptomycin acts by inhibiting protein synthesis in prokaryotes by binding to the 30S ribosomal subunit.5,6,7,8 It has been used, in combination with penicillin G (Item No. 21615), in antibiotic cocktails to prevent bacterial growth in cell culture.9 Formulations containing streptomycin in combination with other antibiotics have been used to treat tuberculosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Syed, H.C., and Ravaoarinoro, M. LiF reduces MICs of antibiotics against clinical isolates of gram-positive and gram-negative bacteria. Int. J. Microbiol. 454065 (2012).

    2. Jhamb, S.S., Goyal, A., and Singh, P.P. Determination of the activity of standard anti-tuberculosis drugs against intramacrophage Mycobacterium tuberculosis, in vitro: MGIT 960 as a viable alternative for BACTEC 460. Braz. J. Infect. Dis. 18(3), 336-340 (2014).

    3. Franzblau, S.G., Witzig, R.S., McLaughlin, J.C., et al. Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay. J. Clin. Microbiol. 36(2), 362-366 (1998).

    4. Lounis, N., Bentoucha, A., Truffot-Pernot, C., et al. Effectiveness of once-weekly rifapentine and moxifloxacin regimens against Mycobacterium tuberculosis in mice. Antimicrob. Agents Chemother. 45(12), 3482-3486 (2001).

    5. Luzzatto, L., Apirion, D., and Schlessinger, D. Mechanism of action of streptomycin in E. coli: Interruption of the ribosome cycle at the initiation of protein synthesis. Proc. Natl. Acad. Sci. USA 60(3), 873-880 (1968).

    6. Moazed, D., and Noller, H.F. Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature 327(6121), 389-394 (1987).

    7. Carter, A.P., Clemons, W.M., Brodersen, D.E., et al. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature 407(6802), 340-348 (2000).

    8. Sharma, D., Cukras, A.R., Rogers, E.J., et al. Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J. Mol. Biol. 374(4), 1065-1076 (2007).

    9. Varghese, D.S., Parween, S., Ardah, M.T., et al. Effects of aminoglycoside antibiotics on human embryonic stem cell viability during differentiation in vitro. Stem Cells Int. 2017, 2451927 (2017).