An adenosine A2A receptor antagonist
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Tozadenant

Item No. 28452

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
CAS Number
870070-55-6
Molecular Formula
C19H26N4O4S
Formula Weight
406.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
255, 284 nm
SMILES
COC1=C(N=C(NC(N2CCC(O)(C)CC2)=O)S3)C3=C(N4CCOCC4)C=C1
InChi Code
InChI=1S/C19H26N4O4S/c1-19(25)5-7-23(8-6-19)18(24)21-17-20-15-14(26-2)4-3-13(16(15)28-17)22-9-11-27-12-10-22/h3-4,25H,5-12H2,1-2H3,(H,20,21,24)
InChi Key
XNBRWUQWSKXMPW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $69

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    25 mg

    $125

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    50 mg

    $214

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    100 mg

    $363

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    Product Description

    Tozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively).1 It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson's disease induced by 6-OHDA (Item No. 25330) when administered at a dose of 30 mg/kg.2 Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson's disease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barret, O., Hannestad, J., Alagille, D., et al. Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys. J. Nucl. Med. 55(10), 1712-1718 (2014).

    2. Michel, A., Downey, P., Van Damme, X., et al. Behavioural assessment of the A2a/NR2B combination in the unilateral 6-OHDA-lesioned rat model: A new method to examine the therapeutic potential of non-dopaminergic drugs. PLoS One 10(8), e0135949 (2015).

    3. Michel, A., Nicolas, J.M., Rose, S., et al. Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets. PLoS One 12(8), e0182887 (2017).