A triterpenoid saponin with diverse biological activities
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Pulchinenoside A

Item No. 28545

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4α)-3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-lup-20(29)-en-28-oic acid
CAS Number
129724-84-1
Synonyms
  • Anemoside A3
Molecular Formula
C41H66O12
Formula Weight
751.0
Purity
≥90%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 5mg/mLDMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
SMILES
CC([C@@H]1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])[C@](C)(CO)[C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7)[C@@H](O)[C@@H](O)CO6)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H])=C
InChi Code
InChI=1S/C41H66O12/c1-20(2)22-10-15-41(36(48)49)17-16-39(6)23(28(22)41)8-9-26-37(4)13-12-27(38(5,19-42)25(37)11-14-40(26,39)7)52-35-33(30(45)24(43)18-50-35)53-34-32(47)31(46)29(44)21(3)51-34/h21-35,42-47H,1,8-19H2,2-7H3,(H,48,49)/t21-,22-,23+,24-,25+,26+,27-,28+,29-,30-,31+,32+,33+,34-,35-,37-,38-,39+,40+,41-/m0/s1
InChi Key
ISNDTNDJSXYNKT-DVIRKNLQSA-N
Origin
Plant/Pulsatilla chinensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.1,2 It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death when used at a concentration of 30 μM.2 Pulchinenoside A (30 and 100 mg/kg) increases the levels of serotonin (5-HT; Item No. 14332), 5-hydroxyindolacetic acid (5-HIAA; Item No. 22889), and norepinephrine (Item No. 16673) in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice. It reduces the time spent immobile in the forced swim test in mice when administered at doses of 30 and 100 mg/kg and increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg. Pulchinenoside A (12.6 and 25.2 mg/kg) reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, D.-M., Lin, S.-M., Lau, C.-W., et al. Anemoside A3-induced relaxation in rat renal arteries: Role of endothelium and Ca2+ channel inhibition. Planta Med. 76(16), 1814-1819 (2010).

    2. Ip, F.C.F., Fu, W.-Y., Cheng, E.Y.L., et al. Anemoside A3 enhances cognition through the regulation of synaptic function and neuroprotection. Neuropsychopharmacology 40(8), 1877-1887 (2015).