Ipragliflozin-¹³C₆

Ipragliflozin-¹³C₆ is intended for use as an internal standard for the quantification of ipragliflozin (Item No. 22287) by GC- or LC-MS. Ipragliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor (IC₅₀ = 7.4 nM in CHO cells expressing the human cotransporter).¹ It is selective for SGLT2 over SGLT1, SGLT3, SGLT4, SGLT5, and SGLT6 (IC₅₀s = 1.9, 30.4, 15.9, 0.46, and 10.4 µM, respectively). Ipragliflozin (0.1-3 mg/kg) decreases plasma levels of insulin and glucose in an oral glucose tolerance test in a mouse model of diabetes induced by high-fat diet, streptozotocin (STZ; Item No. 13104), and nicotinamide (Item No. 11127).² It decreases plasma and hepatic IL-6, TNF-α, chemokine (C-C motif) ligand 2 (CCL2), and C-reactive protein (CRP) levels in the same model when administered at a dose of 3 mg/kg per day for 28 days.

WARNING This product is not for human or veterinary use.

1. Takasu, T., Yokono, M., Tahara, A., et al. In vitro pharmacological profile of ipragliflozin, a sodium glucose co-transporter 2 inhibitor. Biol. Pharm. Bull. 42(3), 507-511 (2019).

2. Tahara, A., Kurosaki, E., Yokono, M., et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur. J. Pharmacol. 715(1-3), 246-255 (2013).