A sapogenin with diverse biological activities
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Panaxatriol

Item No. 28835

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,6β,12β,20R)-20,25-epoxy-dammarane-3,6,12-triol
CAS Number
32791-84-7
Synonyms
  • NSC 308880
Molecular Formula
C30H52O4
Formula Weight
476.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 3mg/mLEthanol: 10mg/mLEthanol:PBS (pH 7.2) (1:5): 0.16mg/mL
SMILES
CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])[C@H](O)C[C@]3(C)[C@]2([H])C[C@@H](O)[C@@]4([H])[C@@]3(C)CC[C@]4([H])[C@]5(C)OC(C)(C)CCC5
InChi Code
InChI=1S/C30H52O4/c1-25(2)12-9-13-30(8,34-25)18-10-15-28(6)23(18)19(31)16-21-27(5)14-11-22(33)26(3,4)24(27)20(32)17-29(21,28)7/h18-24,31-33H,9-17H2,1-8H3/t18-,19+,20+,21+,22-,23-,24-,27+,28+,29+,30+/m0/s1
InChi Key
QFJUYMMIBFBOJY-UXZRXANASA-N
Origin
Plant/Panax ginseng
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $68

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    50 mg

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    100 mg

    $169

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Panaxatriol is a sapogenin that has been found in P. ginseng and has diverse biological activities, including antiproliferative, cardioprotective, and antidiabetic properties.1,2,3 It inhibits the proliferation of DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of reactive oxygen species (ROS) and decreasing the mitochondrial membrane potential.1 Panaxatriol (5 mg/kg) reduces ischemia and reperfusion-induced myocardial dysfunction, increases left ventricular developed pressure (LVDevP) and glutathione (GSH) levels, and decreases cardiac lactate dehydrogenase (LDH), creatine kinase (CK), and malondialdehyde (MDA) levels in rats when administered for seven consecutive days prior to injury.2 Dietary administration of panaxatriol (0.2% for 6 weeks) decreases fasting blood glucose levels in KKAy insulin-resistant mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, R., Zhang, Y., Xu, Z., et al. Potential antitumor effects of panaxatriol against DU-15 human prostate cancer cells is mediated via mitochondrial mediated apoptosis, inhibition of cell migration and sub-G1 cell cycle arrest. J. BUON. 23(1), 200-204 (2018).

    2. Kim, T.-H., and Lee, S.-M. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food Chem. Toxicol. 48(6), 1516-1520 (2010).

    3. Takamura, Y., Nomura, M., Uchiyama, A., et al. Effects of aerobic exercise combined with panaxatriol derived from ginseng on insulin resistance and skeletal muscle mass in type 2 diabetic mice. J. Nutr. Sci. Vitaminol. (Tokyo) 63(5), 339-348 (2017).