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Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.
ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICESGlyphosate is a broad-spectrum, post-emergence herbicide.1 It inhibits the activity of 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSPS; IC50 = 5-7 µM in a cell-free A. aerogenes extract), an enzyme in the shikimate pathway that catalyzes the conversion of shikimic acid to anthranilic acid.2,3 Foliar application of glyphosate induces foliage and rhizome necrosis of johnsongrass (S. halepense) when applied at concentrations ranging from 0.56 to 2.24 kg/hectare.4 It has been found in soil, surface water, and groundwater samples.3 Formulations containing glyphosate have been used for weed control in agriculture and horticulture.
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1. Effect of glyphosate on the microbial activity of two Brazilian soils. Chemosphere 52(5), 799-804 (2003).
2. The herbicide glyphosate is a potent inhibitor of 5-
3. Glyphosate: Its environmental persistence and impact on crop health and nutrition. Plants (Basel) 8(11), 499 (2019).
4. Activity of glyphosate on johnsongrass. Weed Sci. 23(5), 395-400 (1975).