A PDE5 inhibitor
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Mirodenafil (hydrochloride)

Item No. 29045

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one, dihydrochloride
CAS Number
862189-96-6
Synonyms
  • SK3530
Molecular Formula
C26H37N5O5S • 2HCl
Formula Weight
604.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:9): 0.1 mg/mlEthanol: 10 mg/ml
λmax
211, 250 nm
SMILES
O=C1C2=C(C(CCC)=CN2CC)NC(C3=CC(S(N4CCN(CCO)CC4)(=O)=O)=CC=C3OCCC)=N1.Cl.Cl
InChi Code
InChI=1S/C26H37N5O5S.2ClH/c1-4-7-19-18-30(6-3)24-23(19)27-25(28-26(24)33)21-17-20(8-9-22(21)36-16-5-2)37(34,35)31-12-10-29(11-13-31)14-15-32;;/h8-9,17-18,32H,4-7,10-16H2,1-3H3,(H,27,28,33);2*1H
InChi Key
CKPHITUXXABKDL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $134

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    5 mg

    $530

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    10 mg

    $994

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Mirodenafil is a phosphodiesterase 5 (PDE5) inhibitor.1 It increases penile intracavernosal pressure (ICP) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) and in a rat model of cavernosal nerve injury when administered at doses of 1 and 10 mg/kg, respectively.1,2 Mirodenafil (4 mg/kg per day) decreases bladder wall submucosal fibrosis and degeneration in a rat model of chronic bladder ischemia.3 It also decreases bladder overactivity in a female rat model of partial bladder outlet obstruction.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, K., Cho, S.Y., and Kim, S.W. Erectile response to type 5 phosphodiesterase inhibitor could be preserved with the addition of simvastatin to conventional insulin treatment in rat model of diabetes. Int. J. Androl. 34(5 Pt 2), e468-e474 (2011).

    2. Kim, H., Sohn, D.W., Kim, S.D., et al. The effect of mirodenafil on the penile erection and corpus cavernosum in the rat model of cavernosal nerve injury. Int. J. Impot. Res. 22(5), 291-297 (2010).

    3. Choi, H., Bae, J.H., Shim, J.S., et al. Mirodenafil prevents bladder dysfunction induced by chronic bladder ischemia in rats. Int. Neurourol. J. 19(1), 19-26 (2015).

    4. Kang, J.Y., Kim, E.K., and Kim, K.M. Effects of mirodenafil, a phosphodiesterase-5 inhibitor, on female rat bladder in a partial bladder outlet obstruction model: Physiological and immunohistochemical aspects. Korean J. Urol. 54(5), 339-344 (2013).