For immunochemical detection of ERK/MAPK
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ERK/MAPK Polyclonal Antibody

Item No. 29263

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • MAP Kinase
  • Mitogen-activated Protein Kinase
Immunogen
Peptide corresponding to amino acid residues from the C-terminus of rat ERK/MAPK
MW
~44 and 42 kDa for ERK1/MAPK3 and ERK2/MAPK1, respectively
Formulation (Request formulation change)
100 µl of Affinity-purified rabbit polyclonal antibody
Storage Buffer
10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol
Host
Rabbit
Applications
ICC and WB
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $510

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    Product Description

    Extracellular-signal-regulated kinase/mitogen-activated protein kinases (ERK/MAPKs) are a widely conserved family of serine/threonine protein kinases and essential components of the MAP kinase signaling cascade.1,2 Upon extracellular stimulation with mitogens, growth factors, or cytokines, a sequential three-part signaling cascade is initiated that terminates with phosphorylation of ERK/MAPK by MEK1 or MEK2. Activated ERK/MAPK is translocated to the nucleus where it regulates transcription factor activity and gene transcription for a variety of cellular processes including cell proliferation, differentiation, and stress response. Misregulation of the MAP kinase cascade drives development of various cancers. ERK1/MAPK3 and ERK2/MAPK1 are two key members of the ERK/MAPK family encoded by MAPK3 and MAPK1, respectively, in humans and are expressed in all tissues. Cayman’s ERK/MAPK Polyclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications. The antibody recognizes ERK1/MAPK3 and ERK2/MAPK1 at approximately 44 and 42 kDa, respectively from human, mouse, and rat samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Santarpia, L., Lippman, S.L., and El-Naggar, A.K. Targeting the mitogen-activated protein kinase RAS-RAF signaling pathway in cancer therapy. Expert. Opin. Ther. Targets 16(1), 103-119 (2012).

    2. Guo, Y.-J., Pan, W.-W., Liu, S.-B., et al. ERK/MAPK signalling pathway and tumorigenesis. Exp. Ther. Med. 19(3), 1997-2007 (2020).