A xanthine derivative and neuroprotective agent
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Propentofylline

Item No. 29431

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione
CAS Number
55242-55-2
Synonyms
  • HOE 285
  • HWA 285
Molecular Formula
C15H22N4O3
Formula Weight
306.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: slightly solubleChloroform: slightly soluble
λmax
274 nm
SMILES
CCCN(C=N1)C2=C1N(C)C(N(CCCCC(C)=O)C2=O)=O
InChi Code
InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3
InChi Key
RBQOQRRFDPXAGN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $128

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    25 mg

    $241

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    50 mg

    $442

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    Product Description

    Propentofylline is a xanthine derivative and neuroprotective agent.1,2 It increases NGF production in primary mouse astroglia when used at concentrations ranging from 0.12 to 3.33 mM, with the maximum increase observed at 1.11 mM.1 Propentofylline (20 µg/ml) reduces cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons.2 Intravenous infusion of propentofylline (0.01, 0.05, and 0.1 mg/kg per minute) reduces infarct volume in a rat model of ischemic brain damage induced by permanent middle cerebral artery occlusion (MCAO) when administered following MCAO.3 It inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shinoda, I., Furukawa, Y., and Furukawa, S. Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells. Biochem. Pharmacol. 39(11), 1813-1816 (1990).

    2. Koriyama, Y., Chiba, K., and Mohri, T. Propentofylline protects β-amyloid protein-induced apoptosis in cultured rat hippocampal neurons. Eur. J. Pharmacol. 458(3), 235-241 (2003).

    3. Park, C.K., and Rudolphi, K.A. Antiischemic effects of propentofylline (HWA 285) against focal cerebral infarction in rats. Neurosci. Lett. 178(2), 235-238 (1994).

    4. Nagata, K., Ogawa, T., Omosu, M., et al. In vitro and in vivo inhibitory effects of propentofylline on cyclic AMP phosphodiesterase activity. Arzneimittelforschung 35(7), 1034-1036 (1985).

    5. Fredholm, B.B., Fastbom, J., Kvanta, A., et al. Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport. Fundam. Clin. Pharmacol. 6(3), 99-111 (1992).