A dammarane-type triterpene saponin
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Gypenoside IX

Item No. 29705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-3-(β-D-glucopyranosyloxy)-12β-hydroxydammar-24-en-20-yl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside
CAS Number
80321-63-7
Synonyms
  • Notoginsenoside Fd
Molecular Formula
C47H80O17
Formula Weight
917.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
CC1(C)[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)CC[C@@]3(C)[C@@]1([H])CC[C@]4(C)[C@]3([H])C[C@@H](O)[C@@]5([H])[C@@]4(C)CC[C@]5([H])[C@](O[C@@H]6O[C@H](CO[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O)(C)CC/C=C(C)/C
InChi Code
InChI=1S/C47H80O17/c1-22(2)10-9-14-47(8,64-42-39(58)36(55)34(53)27(62-42)21-60-40-37(56)32(51)25(50)20-59-40)23-11-16-46(7)31(23)24(49)18-29-44(5)15-13-30(43(3,4)28(44)12-17-45(29,46)6)63-41-38(57)35(54)33(52)26(19-48)61-41/h10,23-42,48-58H,9,11-21H2,1-8H3/t23-,24+,25+,26+,27+,28-,29+,30-,31-,32-,33+,34+,35-,36-,37+,38+,39+,40-,41-,42-,44-,45+,46+,47-/m0/s1
InChi Key
ZTQSADJAYQOCDD-HUGMCNGHSA-N
Origin
Plant/Gynostemma pentaphyllum (Thunb.) Makino
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $193

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    10 mg

    $328

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    25 mg

    $626

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    50 mg

    $1,060

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    Product Description

    Gypenoside IX is a dammarane-type triterpene saponin that has been found in P. notoginseng.1 It prevents increases in inducible nitric oxide synthase (iNOS), IL-6, and TNF-α levels, as well as phosphorylation of NF-κB, IκB, p38 MAPK, and Akt, induced by LPS and TNF-α in rat C6 glial cells when used at a concentration of 25 μM.2 In vivo, gypenoside IX (30 mg/kg per day) reduces LPS-induced increases in NF-κB, IκB, p38 MAPK, and Akt phosphorylation in mouse brain cortex.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoshikawa, M., Morikawa, T., Kashima, Y., et al. Structures of new dammarane-type triterpene saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal ginseng saponins. J. Nat. Prod. 66(7), 922-927 (2003).

    2. Wang, X., Yang, L., Yang, L., et al. Gypenoside IX suppresses p38 MAPK/Akt/NFκB signaling pathway activation and inflammatory responses in astrocytes stimulated by proinflammatory mediator. Inflammation 40(6), 2137-2150 (2017).