An active metabolite of ifosfamide
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Palifosfamide

Item No. 29887

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′-bis(2-chloroethyl)-phosphorodiamidic acid
CAS Number
31645-39-3
Synonyms
  • Isophosphoramide Mustard
  • NSC 297900
Molecular Formula
C4H11Cl2N2O2P
Formula Weight
221.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
SMILES
ClCCNP(NCCCl)(O)=O
InChi Code
InChI=1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
InChi Key
BKCJZNIZRWYHBN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $37

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    25 mg

    $81

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    50 mg

    $124

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    100 mg

    $194

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    Cayman Chemical
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    Product Description

    Palifosfamide is an active metabolite of the DNA alkylating agent ifosfamide (Item No. 17562).1 Palifosfamide is formed through hydroxylation of ifosfamide by various hepatic cytochrome P450 (CYP) isoforms.2 It is cytotoxic to L1210 and CCRF-CEM cancer cells when used at a concentration of 100 µM.3 Palifosfamide (100 mg/kg per day) reduces tumor growth in murine Lewis lung carcinoma and L1210 leukemia models, as well as a rat Yoshida ascitic sarcoma model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. R.F., S., Dykes, D.J., Corbett, T.H., et al. Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide. Br. J. Cancer 47(1), 15-26 (1983).

    2. Lowenberg, D., Thorn, C.F., Desta, S., et al. PharmGKB summary: ifosfamide pathways, pharmacokinetics and pharmacodynamics. Pharmacogenet. Genom. 24(2), 133-138 (2014).

    3. Zheng, J.J., Chan, K.K., and Muggia, F. Preclinical pharmacokinetics and stability of isophosphoramide mustard. Cancer Chemother. Pharmacol. 33(5), 391-398 (1994).