An alkylating agent used to treat cancer
Related Products
Active Metabolite(s)
29887Palifosfamide
Isomer(s)
13849Cyclophosphamide (hydrate)
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Ifosfamide

Item No. 17562

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
CAS Number
3778-73-2
Synonyms
  • Isophosphamide
  • NSC 109724
Molecular Formula
C7H15Cl2N2O2P
Formula Weight
261.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
ClCCNP1(OCCCN1CCCl)=O
InChi Code
InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
InChi Key
HOMGKSMUEGBAAB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $36

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    100 mg

    $63

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    250 mg

    $103

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    1 g

    $203

    Add
    Cayman Chemical
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    Product Description

    Ifosfamide is a nitrogen mustard alkylating agent used as a chemotherapeutic agent against advanced transitional cell carcinoma.1 It is a structural derivative of cyclophosphamide (Item No. 13849) that was developed for improved solubility and antitumor activity. Like cyclophosphamide, ifosfamide serves as a prodrug that is either metabolized to its active DNA alkylating form, isophosphoramide mustard, or catabolized through a dechloroethylation pathway to the neurotoxic and nephrotoxic chloroacetaldehyde.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perabo, F.G.E., and Müller, S.C. New agents for treatment of advanced transitional cell carcinoma. Ann. Oncol. 18, 835-843 (2007).

    2. Tascilar, M., Loos, W.J., Seynaeve, C., et al. The pharmacologic basis of ifosfamide use in adult patients with advanced soft tissue sarcomas. Oncologist 12, 1351-1360 (2007).