An inhibitor of CYP2C19
Related Products
Isomer(s)
27298(±)-N-3-Benzylnirvanol
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(+)-N-3-Benzylnirvanol

Item No. 30097

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5S)-5-ethyl-5-phenyl-3-(phenylmethyl)-2,4-imidazolidinedione
CAS Number
790676-40-3
Synonyms
  • (S)-N-3-benzyl Nirvanol
Molecular Formula
C18H18N2O2
Formula Weight
294.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O=C(N1CC2=CC=CC=C2)[C@@](C3=CC=CC=C3)(CC)NC1=O
InChi Code
InChI=1S/C18H18N2O2/c1-2-18(15-11-7-4-8-12-15)16(21)20(17(22)19-18)13-14-9-5-3-6-10-14/h3-12H,2,13H2,1H3,(H,19,22)/t18-/m0/s1
InChi Key
ZMZDHUHMXXALFX-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $75

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    5 mg

    $259

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    Product Description

    (+)-N-3-Benzylnirvanol is an inhibitor of the cytochrome P450 (CYP) isoform CYP2C19 (Ki = 0.25 µM).1 It is selective for CYP2C19 over CYP1A2, -2A6, -2C8, -2C9, -2D6, -2E1, and -3A4 at 1 µM and over CYP2B6 (IC50 = 58 µM).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, H., Kneller, M.B., Haining, R.L., et al. (+)-N-3-Benzyl-nirvanol and (−)-N-3-benzyl-phenobarbital: New potent and selective in vitro inhibitors of CYP2C19. Drug Metab. Dispos. 30(3), 235-239 (2002).

    2. Walsky, R.L., and Obach, R.S. Verification of the selectivity of (+)N-3-benzylnirvanol as a CYP2C19 inhibitor. Drug Metab. Dispos. 31(3), 343 (2003).