Isocorydine

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.^1,2,3,4,5 It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 µM.² Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC₅₀ value of 12.6 µM.³ It is cytotoxic to A549 lung cancer cells (IC₅₀ = 197.7 µM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC₅₀s = 161.3, 148, 262.2, and 254.1 µg/ml, respectively).^4,5 Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.⁵

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1. Bhakuni, D.S., Tewari, S., and Dhar, M.M. Aporphine alkaloids of Annona squamosa. Phytochemistry 11(5), 1819-1822 (1972).

2. Zhao, Y.-Q., Li, G.-R., Zhang, D.-Z., et al. Effects of isocorydine on action potentials in isolated canine purkinje fibers and ventricular muscles. J. Mol. Cell. Cardiol. 12(4), 324-327 (1991).

3. Jiang, Q.-S., Huang, X.-N., Sun, A.-S., et al. Relation of vasodilative action of isocorydine to cyclic nucleotides. Chi. J. Pharm. Toxicol. 15(4), 251-255 (2011).

4. Zhong, M., Liu, Y., Liu, J., et al. Isocorydine derivatives and their anticancer activities. Molecules 19(8), 12099-12115 (2014).

5. Pan, J.-X., Chen, G., Li, J.-J., et al. Isocorydine suppresses doxorubicin-induced epithelial-mesenchymal transition via inhibition of ERK signaling pathways in hepatocellular carcinoma. Am. J. Cancer Res. 8(1), 154-164 (2018).