An aporphine alkaloid with diverse biological activities
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Corydine

Item No. 35028

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6,6aS,7-tetrahydro-2,10,11-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-1-ol
CAS Number
476-69-7
Synonyms
  • (+)-Corydine
Molecular Formula
C20H23NO4
Formula Weight
341.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
224 nm
SMILES
OC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=CC=C(OC)C(OC)=C42
InChi Code
InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)19(22)18-16(12)13(21)9-11-5-6-14(23-2)20(25-4)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1
InChi Key
IDQUPXZJURZAGF-ZDUSSCGKSA-N
Origin
Plant/Corydalis edulis Maxim.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $124

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    5 mg

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    10 mg

    $1,041

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    Cayman Chemical
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    Product Description

    Corydine is an aporphine alkaloid that has been found in Corydalis and has diverse biological activities.1,2,3 It inhibits the proliferation of murine L1210 lymphocytic leukemia, B16/F10 melanoma, and P388 leukemia cells when used at concentrations ranging from 10 to 100 µg/ml.1 Corydine binds to μ-opioid receptors (Ki = 2.82 µM) and induces [35S]GTPγS binding in CHO cells expressing human μ-opioid receptors (EC50 = 0.51 µM).2 It also is active against L. donovani promastigotes (IC50 = 26.7 µM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kondo, Y., Imai, Y., Hojo, H., et al. Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine. J. Pharmacobiodyn. 13(7), 426-431 (1990).

    2. Kaserer, T., Steinacher, T., Kainhofer, R., et al. Identifcation and characterization of plant‑derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci. Rep. 10(1), 13804 (2020).

    3. del Rayo Camacho, M., Kirby, G.C., Warhurst, D.C., et al. Oxoaporphine alkaloids and quinones from Stephania dinklagei and evaluation of their antiprotozoal activities. Planta Med. 66(5), 478-480 (2000).