A negative allosteric modulator of mGluR5
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Corypalmine

Item No. 42467

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,8,13,13a-tetrahydro-2,9,10-trimethoxy-6H-dibenzo[a,g]quinolizin-3-ol
CAS Number
27313-86-6
Synonyms
  • Tetrahydrojatrorrhizine
Molecular Formula
C20H23NO4
Formula Weight
341.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly Soluble: 0.1-1 mg/mL
SMILES
OC1=C(OC)C=C(C2N(CC3)CC4=C(C(OC)=CC=C4C2)OC)C3=C1
InChi Code
InChI=1S/C20H23NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,9-10,16,22H,6-8,11H2,1-3H3
InChi Key
BMCZTYDZHNTKPR-UHFFFAOYSA-N
Origin
Plant/Mahoniae Caulis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Corypalmine is an isoquinoline alkaloid that has been found in F. recisa and has receptor antagonist and antifungal activities.1,2 It is an antagonist of dopamine D1, D2, D3, and D5 receptors (Kis = 199, 42.4, 262, and 313 nM, respectively).1 Corypalmine is active against C. albicans, C. glabratas, C. krusei, C. parapsilosis, and C. neoformans (MICs = 160, 160, 320, 160, and 80 µg/ml, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, D.Y.W., Liu, J., Zhang, S., et al. Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. Bioorg. Med. Chem. Lett. 27(6), 1437-1440 (2017).

    2. Rao, G.-X., Zhang, S., Wang, H.-M., et al. Antifungal alkaloids from the fresh rattan stem of Fibraurea recisa Pierre. J. Ethnopharmacol. 123(1), 1-5 (2009).