An OAT1 inhibitor
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4-Hydroxyhippuric Acid

Item No. 30115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-hydroxybenzoyl)-glycine
CAS Number
2482-25-9
Synonyms
  • p-Hydroxyhippuric Acid
  • para-Hydroxyhippuric Acid
Molecular Formula
C9H9NO4
Formula Weight
195.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS (pH 7.2) (1:10): 0.09 mg/ml
λmax
254 nm
SMILES
OC1=CC=C(C(NCC(O)=O)=O)C=C1
InChi Code
InChI=1S/C9H9NO4/c11-7-3-1-6(2-4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
InChi Key
ZMHLUFWWWPBTIU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    Cayman Chemical
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    Product Description

    4-Hydroxyhippuric Acid is a dihydroxy phenolic acid inhibitor of organic anion transporter 1 (OAT1; IC50 = 25 µM in opossum kidney cells).1 It increases the production of free radicals in opossum kidney cells expressing human OAT1. 4-Hydroxyhippuric Acid reduces the secretion of TNF-α, but not IL-1β or IL-6, in isolated human peripheral blood mononuclear cells (PBMCs) stimulated with LPS by 30.4% when used at a concentration of 1 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Motojima, M., Hosokawa, A., Yamato, H., et al. Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake. Br. J. Pharmacol. 135(2), 555-563 (2002).

    2. Monagas, M., Khan, N., Andrés-Lacueva, C., et al. Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells. Br. J. Nutr. 102(2), 201-206 (2009).