A bacterial metabolite and an inhibitor of alkaline phosphatase
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Forphenicine

Item No. 33504

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αS-amino-4-formyl-3-hydroxy-benzeneacetic acid
CAS Number
57784-96-0
Molecular Formula
C9H9NO4
Formula Weight
195.2
Purity
≥90%
Formulation
A solid
SMILES
OC([C@H](C1=CC(O)=C(C=C1)C=O)N)=O
InChi Code
InChI=1S/C9H9NO4/c10-8(9(13)14)5-1-2-6(4-11)7(12)3-5/h1-4,8,12H,10H2,(H,13,14)/t8-/m0/s1
InChi Key
MWSKDGPKFCWPOF-QMMMGPOBSA-N
Origin
Bacterium/Streptomyces fulvoviridis var. acarbodicus MC974-A5
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 mg

    $623

    Add
    Cayman Chemical
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    Product Description

    Forphenicine is a bacterial metabolite that has been found in S. fulvoviridis and an inhibitor of alkaline phosphatase (IC50 = 0.036 µg/ml for the chicken intestine enzyme).1 It inhibits the growth of HL-60 leukemia cells when used at a concentration of 10 µM.2 Forphenicine (50 and 500 µg/animal) increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aoyagi, T., Yamamoto, T., Kojiri, K., et al. Forphenicine, and inhibitor of alkaline phosphatase produced by actinomycetes. J. Antibiot. (Tokyo) 31(3), 244-246 (1978).

    2. Miura, K., Sawa, T., Takeuchi, T., et al. Effects of enzyme inhibitors in inhibiting the growth and inducing the differentiation of human promyelocytic leukemia cells, HL-60. J Antibiot (Tokyo) 39(5), 734-735 (1986).

    3. Aoyagi, T., Wada, T., Nagai, M., et al. Low-molecular-weight enzyme inhibitors suppress the development of experimental allergic encephalomyelitis. Experientia 40(12), 1405-1407 (1984).