A polyphenol metabolite
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3-Hydroxyhippuric Acid

Item No. 37240

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-hydroxybenzoyl)-glycine
CAS Number
1637-75-8
Synonyms
  • m-Hydroxyhippuric Acid
  • meta-Hydroxyhippuric Acid
Molecular Formula
C9H9NO4
Formula Weight
195.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(CNC(C1=CC(O)=CC=C1)=O)O
InChi Code
InChI=1S/C9H9NO4/c11-7-3-1-2-6(4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
InChi Key
XDOFWFNMYJRHEW-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $39

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    50 mg

    $74

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    100 mg

    $138

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    250 mg

    $211

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    Product Description

    3-Hydroxyhippuric acid is a polyphenol metabolite.1 It is an active metabolite of various polyphenols, including the flavonoid (+)-catechin (Item No. 70940), and is formed by glycine conjugation via gut microbiota. 3-Hydroxyhippuric acid inhibits kynureninase (Ki = 60 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gonthier, M.-P., Cheynier, V., Donovan, J.L., et al. Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols. J. Nutr. 133(2), 461-467 (2003).

    2. Lima, S., Kumar, S., Gawandi, V., et al. Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: Insights into the molecular basis of kynureninase substrate specificity. J. Med. Chem. 52(2), 389-396 (2009).