An internal standard for the quantification of miglitol
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Unlabeled Version(s)
15014Miglitol
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Miglitol-d4

Item No. 30139

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-hydroxyethyl-1,1,2,2-d4)-2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol
Molecular Formula
C8H13D4NO5
Formula Weight
211.3
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleWater: soluble
SMILES
OC([2H])([2H])C([2H])([2H])N1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChi Code
InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1/i1D2,2D2
InChi Key
IBAQFPQHRJAVAV-KLVJUPHASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $369

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Miglitol-d4 is intended for use as an internal standard for the quantification of miglitol (Item No. 15014) by GC- or LC-MS. Miglitol is an inhibitor of α-glucosidases (IC50s = 0.35, 0.11, 1.3, and 1.2 µM for human lysosomal α-glucosidase and rat sucrase, maltase, and isomaltase, respectively).1 It is selective for human α- over β-glucosidase (IC50 = 84 µM). Miglitol (10 mg/kg) decreases blood glucose levels in sucrose-loaded Goto-Kakizaki (GK) type 2 diabetic rats.2 Dietary administration of miglitol (40 mg/100 g diet) for 8 weeks decreases changes in HbA1c levels compared with control rats fed a normal diet. Formulations containing miglitol have been used in the treatment of type 2 diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuriyama, C., Kamiyama, O., Ikeda, K., et al. In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg. Med. Chem. 16(15), 7330-7336 (2008).

    2. Goda, T., Suruga, K., Komori, A., et al. Effects of miglitol, an α-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. Br. J. Nutr. 98(4), 702-710 (2007).