An internal standard for the quantification of silodosin
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Unlabeled Version(s)
14866Silodosin
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Silodosin-d4

Item No. 30236

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl-1,1,2,2-d4)amino)propyl)indoline-7-carboxamide
CAS Number
1426173-86-5
Synonyms
  • KMD-3213-d4
Molecular Formula
C25H28D4F3N3O4
Formula Weight
499.6
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
C[C@H](CC1=CC(C(N)=O)=C(N(CCCO)CC2)C2=C1)NC([2H])([2H])C([2H])([2H])OC3=CC=CC=C3OCC(F)(F)F
InChi Code
InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1/i8D2,12D2
InChi Key
PNCPYILNMDWPEY-JRBXURKDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $800

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    Product Description

    Silodosin-d4 is intended for use as an internal standard for the quantification of silodosin (Item No. 14866) by GC- or LC-MS. Silodosin is an α1A-adrenergic receptor (α1A-AR) antagonist (Ki = 0.036 nM).1 It is 583- and 56-fold selective for α1A- over α1B- and α1D-ARs, respectively. Silodosin inhibits phenylephrine-induced contraction of isolated rabbit prostate (pA2 = 10.05) more potently than rabbit or rat aorta (pA2s = 9.36 and 8.13, respectively).2 It inhibits norepinephrine-induced contraction of isolated human prostate tissue when used at concentrations ranging from 0.3 to 10 nM.1 Silodosin (0.01-1,000 µg/kg) inhibits phenylephrine-induced increases in intraurethral pressure in rats.3 Formulations containing silodosin have been used in the treatment of benign prostatic hyperplasia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moriyama, N., Akiyama, K., Murata, S., et al. KMD-3213, a novel α1A-adrenoceptor antagonist, potently inhibits the functional α1-adrenoceptor in human prostate. Eur. J. Pharmacol. 331(1), 39-42 (1997).

    2. Yamagishi, R., Akiyama, K., Nakamura, S., et al. Effect of JMD-3213, an α1a-adrenoceptor-selective antagonist, on the contractions of rabbit prostate and rabbit and rat aorta. Eur. J. Pharm. 315(1), 73-79 (1996).

    3. Akiyama, K., Hora, M., Tatemichi, S., et al. KMD-3213, a uroselective and long-acting α1a-adrenoceptor antagonist, tested in a novel rat model. J. Pharmacol. Exp. Ther. 291(1), 81-91 (1999).