A Bax inhibitor
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Bax Inhibitor Peptide V5 (trifluoroacetate salt)

Item No. 30243

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valyl-L-prolyl-L-methionyl-L-leucyl-L-lysine, trifluoroacetate salt
Synonyms
  • BIP V5
  • VPMLK
Molecular Formula
C27H50N6O6S • XCF3COOH
Formula Weight
586.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C([C@@H](N)C(C)C)N1[C@H](C(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)CCC1.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C27H50N6O6S.C2HF3O2/c1-16(2)15-20(24(35)31-19(27(38)39)9-6-7-12-28)32-23(34)18(11-14-40-5)30-25(36)21-10-8-13-33(21)26(37)22(29)17(3)4;3-2(4,5)1(6)7/h16-22H,6-15,28-29H2,1-5H3,(H,30,36)(H,31,35)(H,32,34)(H,38,39);(H,6,7)/t18-,19-,20-,21-,22-;/m0./s1
InChi Key
PPPNLKRSRNHRDN-QXJGFYJDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $180

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    10 mg

    $339

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Bax inhibitor peptide V5 is an inhibitor of Bax.1 It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-ĸB p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 µM.2 It inhibits apoptosis induced by etoposide (Item No. 12092) in Hep3B human hepatoma cells when used at a concentration of 200 µM.1 Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation.3 Bax inhibitor peptide V5, when used at a concentration of 100 µM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoshida, T., Tomioka, I., Nagahara, T., et al. Bax-inhibiting peptide derived from mouse and rat Ku70. Biochem. Biophys. Res. Commun. 321(4), 961-966 (2004).

    2. Rivas-Carrillo, J.D., Soto-Gutierrez, A., Navarro-Alvarez, N., et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes 56(5), 1259-1267 (2007).

    3. Wang, X., Han, W., Du, X., et al. Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury. Stroke 41(9), 2050-2055 (2010).