A Certified Reference Material of cholic acid
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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Cholic Acid (CRM)

Item No. 44866

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5β-3α,7α,12α-trihydroxy-cholan-24-oic acid
CAS Number
81-25-4
Synonyms
  • CA
  • Cholalic Acid
  • Cholalin
  • NSC 6135
Molecular Formula
C24H40O5
Formula Weight
408.6
Formulation (Request formulation change)
A 1 mg/ml solution in methanol
SMILES
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
InChi Code
InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
InChi Key
BHQCQFFYRZLCQQ-OELDTZBJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Cholic acid (CRM) (Item No. 44866) is a certified reference material categorized as a primary bile acid.1,2 It is produced from cholesterol via a multistep process and is involved in the facilitation of digestion and absorption of dietary lipids and fat-soluble vitamins. Increased serum levels of cholic acid are associated with intrahepatic cholestasis of pregnancy and esophageal adenocarcinoma, and decreased duodenal bile levels of cholic acid are associated with diabetes.3,4,5 This product is intended for use in quantitative analytical research applications. This product is also available as a general research tool (Item Nos. 20250 | 44008).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Šarenac, T.M., and Mikov, M. Bile acid synthesis: From nature to the chemical modification and synthesis and their applications as drugs and nutrients. Front. Pharmacol. 9, 939 (2018).

    2. de Aguiar Vallim, T.Q., Tarling, E.J., and Edwards, P.A. Pleiotropic roles of bile acids in metabolism. Cell Metab. 17(5), 657-669 (2013).

    3. Cheng, C.Y., Zeng, G.Y., Wang, T., et al. Predictive value of serum cholic acid and lithocholic acid for the diagnosis in an intrahepatic cholestasis of pregnancy population with high levels of total bile acids and the correlation with placental hypoxia-inducible factor-1α. Int. J. Womens Health 41, 687-696 (2022).

    4. Kumar, A., Gwalani, P., Iyer, P.G., et al. Shifts in serum bile acid profiles associated with Barrett’s esophagus and stages of progression to esophageal adenocarcinoma. Clin. Transl. Gastroenterol 15(10), e1 (2024).

    5. Andersén, E., Karlaganis, G., and Sjövall, J. Altered bile acid profiles in duodenal bile and urine in diabetic subjects. Eur. J. Clin. Invest. 18(2), 166-172 (1988).