An inhibitor of KAT6A
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WM-1119

Item No. 30509

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-fluoro-5-(2-pyridinyl)-benzoic acid, 2-[(2-fluorophenyl)sulfonyl]hydrazide
CAS Number
2055397-28-7
Molecular Formula
C18H13F2N3O3S
Formula Weight
389.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.25 mg/ml
λmax
223, 277 nm
SMILES
FC1=CC(C(NNS(C2=C(F)C=CC=C2)(=O)=O)=O)=CC(C3=NC=CC=C3)=C1
InChi Code
InChI=1S/C18H13F2N3O3S/c19-14-10-12(16-6-3-4-8-21-16)9-13(11-14)18(24)22-23-27(25,26)17-7-2-1-5-15(17)20/h1-11,23H,(H,22,24)
InChi Key
QLXULUNLCRKWRD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $121

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    10 mg

    $215

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    25 mg

    $448

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    50 mg

    $713

    Add
    Cayman Chemical
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    Product Description

    WM-1119 is an orally bioavailable inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ; IC50 = 6.3 nM).1 It binds to KAT6A with a Kd value of 2 nM and is selective for KAT6A over KAT5 and KAT7 (Kds = 2,200 and 500 nM, respectively), as well as over a panel of 159 additional targets at 1 and 10 μM.2 WM-1119 inhibits proliferation of EMRK1184 B cell lymphoma cells (IC50 = 0.25 μM). It reduces tumor growth and spleen weight in a murine EMRK1184 model when administered at a dose of 50 mg/kg four times per day. See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Priebbenow, D.L., Leaver, D.J., Nguyen, N., et al. Discovery of acylsulfonohydrazide-derived inhibitors of the lysine acetyltransferase, KAT6A, as potent senescence-inducing anti-cancer agents. J. Med. Chem. 63(9), 4655-4684 (2020).

    2. Baell, J.B., Leaver, D.J., Hermans, S.J., et al. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 560(7717), 253-257 (2018).