An Analytical Reference Material of hydroxychloroquine
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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Hydroxychloroquine (sulfate)

Item No. 30709

Synonyms
Synonyms
  • HCQ
  • NSC 4375
Technical Information
Formal Name
2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-ethanol, monosulfate
CAS Number
747-36-4
Molecular Formula
C18H26ClN3O • H2SO4
Formula Weight
Purity
≥98%
A neat solid
SMILES
CC(CCCN(CC)CCO)NC1=CC=NC2=CC(Cl)=CC=C21.O=S(O)(O)=O
InChi Code
InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChi Key
JCBIVZZPXRZKTI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Hydroxychloroquine (sulfate) (Item No. 30709) is an analytical reference material categorized as an antimalarial, anti-inflammatory, and antiviral agent.1,2,3,4 Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro.4 Formulations containing hydroxychloroquine have been associated with fatal overdoses.5 This product is intended for analytical research applications. This product is also available as a general research tool (Item No. 17911).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Delves, M., Plouffe, D., Scheurer, C., et alThe activities of current antimalarial drugs on the life cycle stages of Plasmodium: A comparative study with human and rodent parasites. PLoS Med. 9(2), e1001169 (2012).

    2. Mauthe, M., Orhon, I., Rocchi, C., et alChloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy 14(8), 1435-1455 (2018).

    3. da Silva, J.C., Mariz, H.A., da Rocha, L.F., Jr., et alHydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients. Clinics (Sao Paulo) 68(6), 766-771 (2013).

    4. Maisonnasse, P., Guedj , J., Contreras, V., et alHydroxychloroquine use against SARS-CoV-2 infection in non-human primates. Nature 585(7826), 584-587 (2020).

    5. Marquardt, K., and Albertson, T.E. Treatment of hydroxychloroquine overdose. Am. J. Emerg. Med. 19(5), 420-424 (2001).