A BRD inhibitor
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XD14

Item No. 30740

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide
CAS Number
1370888-71-3
Molecular Formula
C20H27N3O5S
Formula Weight
421.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
λmax
238, 307 nm
SMILES
O=S(C1=CC(NC(C2=C(CC)C(C(C)=O)=C(C)N2)=O)=C(O)C=C1)(N(CC)CC)=O
InChi Code
InChI=1S/C20H27N3O5S/c1-6-15-18(13(5)24)12(4)21-19(15)20(26)22-16-11-14(9-10-17(16)25)29(27,28)23(7-2)8-3/h9-11,21,25H,6-8H2,1-5H3,(H,22,26)
InChi Key
DPBKLIVPNYGQQG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $129

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    10 mg

    $231

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    25 mg

    $510

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    50 mg

    $888

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    Cayman Chemical
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    Product Description

    XD14 is a bromodomain-containing protein (BRD) inhibitor.1 It binds to BRD2, -3, and -4 (Kds = 170, 380, and 160 nM) and inhibits the growth of HL-60 cells (GI50 = ~20 µM). XD14 (10 µM) also inhibits the growth of SR, K562, and MOLT-4 leukemia cells, as well as T47D breast, UO-31 renal, IGROV-1 ovarian, and KM12 colon cancer cells in vitro.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lucas, X., Wohlwend, D., Hügle, M., et al. 4-Acyl pyrroles: Mimicking acetylated lysines in histone code reading. Angew. Chem. Int. Ed. Engl. 52(52), 14055-14059 (2013).