A probucol derivative with diverse biological activities
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Succinobucol

Item No. 30886

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
butanedioic acid, 1-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl] ester
CAS Number
216167-82-7
Synonyms
  • AGI-1067
  • Probucol Monosuccinate
Molecular Formula
C35H52O5S2
Formula Weight
616.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
CC(C)(C)C1=CC(SC(C)(C)SC2=CC(C(C)(C)C)=C(OC(CCC(O)=O)=O)C(C(C)(C)C)=C2)=CC(C(C)(C)C)=C1O
InChi Code
InChI=1S/C35H52O5S2/c1-31(2,3)23-17-21(18-24(29(23)39)32(4,5)6)41-35(13,14)42-22-19-25(33(7,8)9)30(26(20-22)34(10,11)12)40-28(38)16-15-27(36)37/h17-20,39H,15-16H2,1-14H3,(H,36,37)
InChi Key
RKSMVPNZHBRNNS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $91

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    25 mg

    $202

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    50 mg

    $355

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    100 mg

    $662

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.1,2,3 It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.1 Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.2 Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.3 It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kunsch, C., Luchoomun, J., Grey, J.Y., et al. Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent. J. Pharmacol. Exp. Ther. 308(3), 820-829 (2004).

    2. Wasserman, M.A., Sundell, C.L., Kunsch, C., et al. Chemistry and pharmacology of vascular protectants: a novel approach to the treatment of atherosclerosis and coronary artery disease. Am. J. Cardiol. 91(3A), 34A-40A (2003).

    3. Sundell, C.L., Somers, P.K., Meng, C.Q., et al. AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent. J. Pharmacol. Exp. Ther. 305(3), 1116-1123 (2003).